I. Profile
The Engineering Laboratory, always adhering to the innovative thinking of “clinical and market”, not only pays attention to “technical advancement and innovation”, but also pays attention to “technical maturity, compatibility and applicability”, upholding the cooperation concept “scientists truly entering the enterprise value chain”. Aiming at major diseases such as wound repair, bacterial infections, tumors, diabetes, cardiovascular and cerebrovascular diseases and neurodegenerative diseases, and based on the design and construction of biomedical materials, it explores the latest advances in medicine, pharmacy and biology, focuses on the key common technical issues in the development of biomedical materials technology, and carries out related application research and technology development research. There are three research directions under the Laboratory: medical antibacterial materials, nano-biomaterials, and medical imaging materials.
II. The Team
The Laboratory has 28 team members, including 12 professors, 11 associate professors, 26 PhDs (taking 93% of the total staff), 2 Leaders of Youth Innovation Team for universities in Shandong, and 1 innovative talent in the Double-Hundred Plan of Yantai City. The team members have multidisciplinary research talents such as medicinal chemistry, materials science, organic chemistry, pharmacy, physical chemistry, pharmaceutical analysis and pharmacology, and have rich research experience in medical antibacterial materials, nano-biomaterials, and medical imaging materials.
III. Academic Achievements
In order to solve the problems of high industrialization technical barriers, high R&D costs, and long R&D cycles in the research and development of biomedical materials, the “engineering laboratory” has made breakthroughs and innovations in the following three aspects:
1) In the research and development of medical antibacterial materials: developing new nanometer antibacterial materials with good biocompatibility, using chitosan and silicone to find solutions for key technology for high antibacterial activity and low cytotoxicity compatible quaternary ammonium modification, in order to obtain the pilot sample, and use it as the main material to further develop the preparation technology of fiber-based medical composite materials based on electrospinning and self-assembly, thus giving the material multiple functions such as hemostatic repair, antibacterial, anti-inflammatory, and scar repair .
2) In terms of research and development of nano-biomaterials: developing a new type of combined nano-drug delivery system based on serum albumin and liposomes, and solving the key scientific problems of strong toxicity and resistance to drug resistance in the existing clinical anti-tumor chemotherapeutic drug system. In response to the microenvironment such as high glutathione, it adopts innovative process routes with independent intellectual property rights to achieve key technological breakthroughs in the direction of new nano-biomaterials for drug delivery. It explores a set of low-toxicity, high-efficiency, accurate diagnosis and treatment integrated tumor treatment plan, and constructs a series of multifunctional nano-biomedical materials with good biocompatibility.
3) In the aspect of medical imaging materials research and development: through the design of a variety of nanosystems (gadolinium ion doped iron oxide nanocrystal clusters, acylhydrazone bond grafting doxorubicin, net-like hydrogenated silica encapsulated GIONC core-shell structure, oxidation The egg shell structure of gadolinium and iron oxide, the peanut structure of gadolinium iron nanocomposite), a batch of anti-tumor MRI contrast agents with industrialization prospects have been screened, which greatly improves the performance of dual-mode MRI technology. Accurate diagnosis and targeted therapy of tumors provide an important reference.
IV. Infrastructure
The Laboratory has a school-level medical material research institute, a first-class campus GMP laboratory and a process research center in the province, with a total laboratory area of 1370 square meters and a total equipment value of more than RMB 45 million yuan.
First of all, it has a school-level medical materials research institute, which consists of a medical materials laboratory, an antibacterial laboratory, a cell culture room, a drug synthesis room, an analysis and testing center, and a pharmacodynamic activity center. Equipped with basic experimental facilities for overall research from molecules to cells to living animals, providing a platform for the preparation of functional materials such as medical antibacterial materials, wound repair materials, medical antitumor materials, medical detection materials, breakthroughs in key technologies, and related application transformation platform.
Secondly, through in-depth cooperation with Shandong Xianglong Pharmaceutical Research Institute, it has built a first-class campus GMP laboratory and process research center in the province, with total value of scientific research equipment of more than 20 million yuan, which can meet the needs of the transformation of scientific research results from small-scale to pilot-scale.
Thirdly, the cooperative units include Shandong International Biotechnology Park Development Co., Ltd., Shandong Xianglong Pharmaceutical Research Institute Co., Ltd. and Shandong Hierde Material Technology Co., Ltd., mainly providing the basic technical services such as necessary equipment, information, technology, and talents. In addition, focusing on the various drugs loaded in biomedical materials, it has established industry-university-research cooperation agreements with Yantai University, Shanghai Institute of Materia Medica, Ludong University, Runhui Pharmaceutical, Junxiu Biological, Zhenghai Biological, Yantai Hierde Materials, etc. At present, staged success has been achieved in the research of antibacterial materials, anti-tumor materials and imaging materials.
