I. Profile
The Binzhou 3D Printing Medical Key Laboratory is located in the comprehensive building of the Affiliated Hospital of Binzhou Medical University, covering an area of 500 square meters. The current laboratory is mainly divided into two parts: 1. 3D printing room clinical research center, which is mainly responsible for 3D printing research such as clinical anatomy and surgery. It also includes teaching conferences on 3D printing and the application of national continuing education projects. It now has 12 sets of 3D printers, more than 30 sets of supporting computer equipment, 1 multimedia conference center. 2. 3D printing basic research center, mainly responsible for biological 3D printing research. It mainly includes routine biological research, morphological observation, immunohistochemistry, in situ hybridization, immunofluorescence, genetic testing, cell culture loop tumor cell testing and molecular biology laboratory, etc. It is equipped with 1 PCR machine, 1 ultra-clean workbench, 1 low temperature and high speed 80℃ refrigerator, 1 confocal microscope, 1 cell incubator, 1 flow cytometer, etc. The current laboratory work partitions and instruments can meet the needs of scientific research staff.
The Laboratory has established three scientific research teams for cerebrovascular disease, neurotumor and digital neurosurgery, and the scientific research personnel and scientific research strength have been continuously strengthened. Under the leadership of Professor Li Zefu, it has undertaken 1 National Natural Science Foundation project (General Project), 2 Shandong Natural Science Foundation projects, 5 Shandong Medical and Health Science and Technology Plans, and 9 Science and Technology Development Plans of the Affiliated Hospital of Binzhou Medical University and won 1 second prize of Science and Technology Innovation Achievement Award and 1 second prize of Binzhou Science and Technology Award.
II. The Team
There are 22 permanent staff members in the Laboratory, including 2 professors, 5 associate professors (associate chief physicians), 3 doctors, 6 doctors and masters students, 7 of them having overseas study or short-term research experiences. The Laboratory focuses on the echelon construction of academic teams and has established a good technical team. The academic leaders of each research direction are associate professors or above with rich publications. The backbone of scientific research in the academic echelon has obtained a number of doctoral degrees and has a relatively high level of scientific research.
III. Academic Achievements
The Laboratory has established three scientific research teams for cerebrovascular disease, neurotumor and digital neurosurgery, and the scientific research personnel and scientific research strength have been continuously strengthened. Under the leadership of Professor Li Zefu, it has undertaken 1 National Natural Science Foundation project (General Project), 2 Shandong Natural Science Foundation projects, 5 Shandong Medical and Health Science and Technology Plans, and 9 Science and Technology Development Plans of the Affiliated Hospital of Binzhou Medical University and won 1 second prize of Science and Technology Innovation Achievement Award and 1 second prize of Binzhou Science and Technology Award.
In the past five years, Laboratory researchers have been engaged in the research of 3D printing cerebrovascular diseases. The research projects have been funded by a number of provincial and municipal projects, and have been rewarded for scientific research achievements at the provincial and municipal levels. Researchers have formed three relatively stable research directions in the field of cerebrovascular research: the application of 3D printing guide plates in hypertensive cerebral hemorrhage, the application of 3D printing in microcatheter modeling the application of 3D printing in lateral ventricle puncture . The main research results and progress are as follows:
The application of 3D printed guides in hypertensive cerebral hemorrhage is mainly to use 3D printed guides for precise surgical positioning and puncture. Hypertensive intracerebral hemorrhage is a high incidence at the Yellow River Delta, with a high fatality rate and a high disability rate. Accurate surgical positioning is critical to the prognosis of patients. Under the leadership of Professor Li Zefu, the research team has been committed to the study of hypertensive cerebral hemorrhage, through the patient's impact data, preoperative surgical planning, setting the puncture path, and printing the solid guide model through 3D printing technology. As a result, precise hematoma location, large sample clinical trials have been conducted in transfrontal puncture, transtemporal puncture, and cerebellar brainstem puncture, providing new ideas for surgical positioning of hypertensive intracerebral hemorrhage and improving the prognosis of patients. A patent has been applied for the results of this research. In addition, the Laboratory is also committed to the application of 3D technology in neurointerventional surgery. Neurointervention is an important branch of neurosurgery. This technique is minimally invasive and effective, but the operation is more difficult and the learning curve is gentle. Microcatheter plastic technology is a major difficulty in interventional surgery, which requires high technical experience for the surgeon. Using 3D printing technology, a 1:1 blood vessel model is printed, fast and being able to be completed within half an hour before surgery. Compared with the traditional shaping process, the accuracy of microcatheter shaping is improved. The microcatheter model provides a more intuitive spatial form, and the shaping length of the microcatheter is the actual length of the tube in the artery, which can be directly compared, and the precise length can be directly measured in the software workstation. The model material is photosensitive resin, which is flexible and bendable, and helps to solve the problem of springback after the micropipette is shaped. This study has applied for an invention patent and conducted a retrospective clinical study.
Nerve tumors are important diseases that threaten the health of patients. With the development of microneurosurgery, neuronavigation technology is gradually applied in intracranial tumor surgery, which can assist in accurately positioning the lesion. However, the cost of neuronavigation is high and the price is expensive. We collected tumor patient imaging data and used Mimics17.0 software to reconstruct the patient’s imaging data into a three-dimensional image, and then we designed and produced individualized 3D printed guides with tumor location markers, which can accurately locate meningioma before surgery and achieve good results. Effect.
IV. Infrastructure
The Binzhou 3D Printing Medical Key Laboratory is located in the comprehensive building of the Affiliated Hospital of Binzhou Medical University, covering an area of 500m2. The current laboratory is mainly divided into two parts: 1. 3D printing room clinical research center, which is mainly responsible for 3D printing research such as clinical anatomy and surgery. It also includes teaching conferences on 3D printing and the application of national continuing education projects. It now has 12 sets of 3D printers, more than 30 sets of supporting computer equipment, 1 multimedia conference center. 2. 3D printing basic research center, mainly responsible for biological 3D printing research. It mainly includes routine biological research, morphological observation, immunohistochemistry, in situ hybridization, immunofluorescence, genetic testing, cell culture loop tumor cell testing and molecular biology laboratory, etc. It is equipped with 1 PCR machine, 1 ultra-clean workbench, 1 low temperature and high speed 80℃ refrigerator, 1 confocal microscope, 1 cell incubator, 1 flow cytometer, etc. The current laboratory work partitions and instruments can meet the needs of scientific research staff.
