Geng Tian, PhD
Tenure-track professor and doctoral supervisor of Cell biology
Director of the Department of Academic Affairs and the Department of Postgraduates of Binzhou Medical University
Director of Shandong Technology Innovation Center of Molecular Targeted Intelligent Therapy
Research Fields
1.Metabolic diseases;
2.Precision medicine research of Major chronic diseases；
3.Transformation and application of targeted nanodrugs；
4.Transformation and application of- high throughput protein detection technology-QDB technology
Representative Research Papers
1. Deng T, Li J, Liu J, Xu F, Liu X, Mi J, Bergquist J, Wang H, Yang C, Lu L, Song X, Yao C, Tian G, Zheng Q. Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice. Front Neurosci. 2021 November 17.
2. Zhu W, Ding Z, Zhang Z, Wu X, Liu X, Zhang Ya, Li S, Zhou L, Tian G, Qin J.Enhancement of Oxytocin in the Medial Prefrontal Cortex Reverses Behavioral Deficits Induced by Repeated Ketamine Administration in Mice. Front. Neurosci, 2021 September 10.
3. Zhang G, Zhang L, Si Y, Li Q, Xiao J, Wang B, Liang C, Wu Z, Tian G. Oxygen-enriched Fe3O4/Gd2O3 nanopeanuts for tumor-targeting MRI and ROS-triggered dual-modal cancer therapy through platinum (IV) prodrugs delivery. Chemical Engineering Journal. 2020 Feb 1,388 :124269
4. Zhang G, Xie W, Xu Z, Si Y, Li Q, Qi X, Gan Y, Wu Z, Tian G. CuO dot-decorated Cu@Gd2O3 core–shell hierarchical structure for Cu(I) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy. Materials Horizons. 2020 Dec.
5. Li Z, Wang Q, Luan H, Yang M, Li Y, Tian G, He W. A novel target TAX1BP1 and P38/Nrf2 pathway independently involved in the anti-neuroinflammatory effect of isobavachalcone. Free Radical Biology and Medicine. 2020 Apr; 153:132–139.
6. Zhu Y, Zhang C, Xu F, Zhao M, Bergquist J, Yang C, Liu X, Tan Y, Wang X, Li S, Jiang W, Ong Q, Lu L, Mi J, Tian G. System biology analysis reveals the role of voltage-dependent anion channel in mitochondrial dysfunction during non-alcoholic fatty liver disease progression into hepatocellular carcinoma. Cancer Sci. 2020 Nov;111(11):4288-4302.
7. Liu X, Heras G, Lauschke VM, Mi J, Tian G, Gastaldello S. High glucose-induced oxidative stress accelerates myogenesis by altering SUMO reactions. Exp Cell Res. 2020 Oct 15;395(2):112234.
8. Zhang Y, Wang D, Li M, Wei X, Liu S, Zhao M, Liu C, Wang X, Jiang X, Li X, Zhang S, Bergquist J, Wang B, Yang C, Mi J, Tian G. Quantitative Proteomics of TRAMP Mice Combined with Bioinformatics Analysis Reveals That PDGF-B Regulatory Network Plays a Key Role in Prostate Cancer Progression. J Proteome Res. 2018 Jul;17(7):2401-2411.
9. Qi X, Zhang Y, Zhang Y, Ni T, Zhang W, Yang C1, Mi J, Zhang J, Tian G. High Throughput, Absolute Determination of the Content of a Selected Protein at Tissue Levels Using Quantitative Dot Blot Analysis (QDB). J Vis Exp. 2018 Aug; 21: (138).
10. Tian G, Tang F, Yang C,Zhang W, Berguist J, Wang B, Mi J, Zhang J*. Quantitative dot blot analysis (QDB), a versatile high throughput immunoblot method. Oncotarget 2017, 8(35):58553-58562.
11. Tian G, Sol ER, Xu Y, Shuai H, Tengholm A. Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate. Diabetes. 2015 Mar;64(3):904-15.
12. Tian G, Sågetorp J, Tengholm A: Phosphodiesterases shaping of sub-plasma membrane cAMP oscillations and exocytosis in pancreatic β-cells. J Cell Sci. 2012 Nov;125(Pt 21):5084-95
13. Tian G, Tepikin AV, Tengholm A, Gylfe E: cAMP induces stromal interaction molecule 1 (STIM1) Puncta but neither orai1 clustering nor store-operated Ca2+ entry (SOCE) in islet cells. J Biol Chem, 2012 Mar 23;287(13):9862-72012.
14. Tian G, Sandler S, Gylfe E, Tengholm A: Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets. Diabetes. 2011,60:1535-1543.
15. Dyachok O, Idevall-Hagren O, Sagetorp J, Tian G, Wuttke A, Arrieumerlou C, Akusjarvi G, Gylfe E, Tengholm A: Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion. Cell Metab. 2008,8:26-37.
16. Tian G, Yu Y, Singh U, Sun T, Fundele R. Functional analysis of LIM homeobox family genes in development of the mouse placenta. Dev Dyn. 2008,237(5):1517-25,
Research Projects
1. National Natural Science Fund, General Program, 31771284, Investigating the insulin secretion mechanism regulated by AC9 with pancreatic β cell specific AC9 knockout mice, 01/01/2018-12/31/2021.
2. National Natural Science Fund, Youth Fund, 81400771, Investigating the role of adenylyl cyclase 6 in insulin secretion by using a novel fluorescent cAMP biosensor, 01/01/2015-12/31/2017.
3. People's Government of Shandong Province, Shandong Youth Taishan scholar Grand, 01/01/2017-12/31/2021.
4. Major basic research projects of Natural Science Foundation of Shandong Province, ZR2019ZD27, Research on the neural mechanisms and intervention of co-morbid psychiatric disorders in metabolic syndrome, 12/01/2019-12/31/2024.
5. Special Project of Central Government for Local Science and Technology Development of Shandong Province, YDZX20203700001291,01/01/2019-12/31/2022.
6. Shandong Province Higher Educational Youth Innovation Science and Technology , 2019KJE013, Development and application of multifunctional fluorescent molecular probes in clinical diagnosis, 01/01/2019-12/31/2024.
7. Research Award Fund for Outstanding Youth Talent in Higher Education Institutions of Shandong, ZR2016JL026, Precision medicine in diabetes research, 01/01/2017-12/01/2021.
8. Integrated development project between colleges and enterprises in Yantai City, 2019XDRHXMPT14, R&D center for molecular diagnostics for precision medicine, 01/01/2019-12/31/2021.
9. Key Research and Development Plan of Shandong Province, 2018GSF118230, Mechanisms researchof retinal protection by VEGF-B in non-proliferative diabetic retinopathy, 01/01/2018-12/31/2019.
10. National Key Laboratory of Ophthalmology, Quantitative proteomics analysis of the protective mechanism of VEGF-B on glaucomatous retinal cells. 01/01/2018-12/31/2019.
Academic Employment
Representative of the 18th National Congress of the Communist Youth League;
Representative of the 13th National People's Congress of Shandong Province;
Member of the 10th Committee of the All-China Federation of Returned Overseas Chinese;
Member of the Standing Committee of Shandong Association for Science and Technology;
Vice chairman of Young Scientists Association of Shandong Province;
Deputy secretary of the Communist Youth League of Yantai Municipal Committee;
Chairman of the Federation of Returned Overseas Chinese of Binzhou Medical University;
President of the Western Returned Scholars Association of Binzhou Medical University.
