Yongfeng Gong, MD, PhD
Professor of Physiology
Deputy Dean, School of Basic Medical Science, Binzhou Medical University
Research Fields
1. Tight junction dysfunction and disease pathogenesis;
2. Tight junction physiology and pathophysiology;
3. Regulation of paracellular permeability.
Representative Research Papers
1. Gong Y, Renigunta V, Himmerkus N, Zhang J, Renigunta A, Bleich M, Hou J. Claudin-14 regulates renal Ca++ transport in response to CaSR signaling via a novel microRNA pathway. EMBO J.2012 31(8):1999-2012.
2. Gong Y, Hou J. Claudin-14 underlies CaSR mediated Ca++ metabolism via NFAT-microRNA based mechanisms. J Am Soc Nephrol.2014; 25:745-60.
3. Gong Y, Himmerkus N, Plain A, Bleich M, Hou J. Epigenetic Regulation of MicroRNAs Controlling CLDN14 Expression as a Mechanism for Renal Calcium Handling. J Am Soc Nephrol.2015 Mar;26(3):663-76.
4. Gong Y, Yu M, Yang J, Gonzales E, Perez R, Hou M, Tripathi, P, Hering-Smith K, Hamm LL, Hou J. The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation. Proc Natl Acad Sci U S A.2014 Sep 9; 111(36):E3766-74.
5. Gong Y, Wang J, Yang J, Gonzales E, Perez R, Hou J. KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A.2015 Apr 7; 112(14):4340-5.
6. Gong Y, Renigunta V, Zhou Y, Wang J, Yang J, Renigunta A, Baker LA, Hou J. Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization. Mol Biol Cell.2015 Dec 1;26(24):4333-46.
7. Gong Y*, Sunq A, Roth RA, Hou J*. Inducible Expression of Claudin-1 in Glomerular Podocytes Generates Aberrant Tight Junctions and Proteinuria through Slit Diaphragm Destabilization. J Am Soc Nephrol. 2017 Jan;28(1):106-117.
8. Zhou L, Gong Y, Sunq A, Hou J, Baker LA. Capturing Rare Conductance in Epithelia with Potentiometric-Scanning Ion Conductance Microscopy. Anal Chem. 2016 Oct 4; 88(19):9630-9637.
9. Gong Y, Hou J. Claudins in barrier and transport function-the kidney. Pflugers Arch. 2017 Jan; 469(1):105-113.
10. Gong Y, Himmerkus N, Sunq A, Milatz S, Merkel C, Bleich M, Hou J. ILDR1 is important for paracellular water transport and urine concentration mechanism. Proc Natl Acad Sci U S A. 2017 May 16;114(20):5271-5276.
11. Cain MD, Salimi H, Gong Y, Yang L, Hamilton SL, Heffernan JR, Hou J, Miller MJ, Klein RS. Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection. J Neuroimmunol. 2017 Jul 15;308:118-130.
12. Zhou L, Gong Y,Hou J, Baker LA. Quantitative Visualization of Nanoscale Ion Transport. Anal Chem. 2017 Dec 19;89(24):13603-13609.
13. Greene C, Kealy J, Humphries MM, Gong Y, Hou J, Hudson N, Cassidy LM, Martiniano R, Shashi V, Hooper SR, Grant GA, Kenna PF, Norris K, Callaghan CK, Islam MD, O'Mara SM, Najda Z, Campbell SG, Pachter JS, Thomas J, Williams NM, Humphries P, Murphy KC, Campbell M. Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. Mol Psychiatry. 2018 Nov;23(11):2156-2166.
14. Sun H, Li H, Yan J, Guo H, Liu J, Wang M, Lin N, Wang X, Wang X, Li L, Zhao S, Gong Y. Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease. Research Square Preprint. 10.21203/rs.3.rs-285550/v1. Nature Communication. In Revision.
Research Projects
1. National Natural Science Fund, General Program, 81670620, The mechanistic role of tight junction protein Claudin-1 under nephrotic conditions，01/01/2017-12/31/2020
2. National Natural Science Fund, General Program, 81870485, The mechanistic roles of Paracellular Chloride Channel in Gordon's syndrom，01/01/2019-12/31/2022
Academic Employment
Vice Chairman of Shandong Physiological Society;
Youth Member of Renal Committee of Chinese Physiological Society;
Special Reviewer of Tissue Barriers, Journal of Clinical Nephrology and Research, Journal of Cellular Physiology, etc.
