Lyu Changjun, MD, PhD, Professor
Vice President of Binzhou Medical University
He enjoys the Special Allowance from the State Council and is awarded titiles of "National Health System Advanced Worker", "National Excellent Hospital Director" and "Advanced Individual in the Fight against SARS" (first-class merit) by Shandong Provincial Committee of the Communist Party of China, and the Provincial Government.
Research Fields
1. the Pathogenesis of Interstitial Lung Disease Mediated by Non-coding genes;
2. Screening and Identification of Biomarkers of Interstitial Lung Disease;
3. R&D of Drugs for Interstitial Lung Disease;
4. Promotion of Pulmonary Rehabilitation Technology for Patients with Pulmonary Fibrosis;
5. R&D of Visual Diagnosis Technology for Pulmonary Fibrosis.
Representative Academic Papers
1. Shen K#, Li R#, Zhang X#, Qu G, Li R, Wang Y, Liu B, Lv C, Li M*, Song X*. Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFβ1-smad/p38MAPK-lnc865/lnc556-miR-29b-2-5p-STAT3 signal pathway. Aging (Albany NY). 2021 Apr 30;13(10):13807-13821.
2. Zhang S#, Chen H#, Yue D, Blackwell TS, Lv C, Song X*. Long non-coding RNAs: Promising new targets in pulmonary fibrosis. J Gene Med. 2021;23(3):e3318. doi:10.1002/jgm.3318.
3. He N#, Wang Y#, Huang Y, Chen L*, Wang X, Lv C*, Yue S. Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models. J Mater Chem B 2020;8(43):9899-9905.
4. Chen H#, Wang J#, Li R#, Lv C, Xu P, Wang Y, Song X*, Zhang J*. Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria-mediated signal pathways. J Cell Mol Med. 2020 Sep;24(17):10245-10250.
5. Zhang J#, Chen X#, Chen H#, Li R, Xu P, Lv C, Liu B*, Song X*. Engeletin ameliorates pulmonary fibrosis through endoplasmic reticulum stress depending on lnc949-mediated TGF-β1-Smad2/3 and JNK signalling pathways. Pharm Biol. 2020 Dec;58(1):1105-1114.
6. He N#, Wang Y#, Huang Y*, Wang X, Chen L*, Lv C*. A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models. Sensors and Actuators B: Chemical 2020;322.
7. Li W#, Yu Y#*, Li D#, Xu N, Fang J, Sun Y, Xu M, Wang X, Han X, Zhang X, Lv C*, Han F*. TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits. Int Immunopharmacol 2020;81:106284.
8. Zhai N#,Liu J, Xu P, Liu B, Fan Y, Lv C*. Pulmonary metastasis of distal cholangiocarcinoma with multiple cavities in bilateral lungs: A case report. Thorac Cancer. 2020;11(10):2998-3000.
9. Song X#, Xu P#, Meng C#, Song C, Li R, Li H, Zhang J*, Lv C*. LncITPF Promotes Pulmonary Fibrosis by Targeting hnRNP L Depending on Its Host Gene ITGBL1. Molecular Therapy 2019;27(2):380-393.
10. Li C#, Wang Z#, Zhang J#, Zhao X, Xu P, Liu X, Li M, Lv C*, Song X*. Crosstalk of mRNA, miRNA, lncRNA, and circRNA and Their Regulatory Pattern in Pulmonary Fibrosis. Mol Ther Nucleic Acids 2019; 18:204-218.
11. He N#, Bai S#, Huang Y, Xing Y, Chen L*, Yu F*, and Lv C*. Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near- Infrared Fluorescent Probe in Cell and Mice Models. Analytical Chemistry 2019;91(8):5424-32.
12. Zhang X#, He N, Huang Y, Yu F*, Li B, Lv C*, Chen L*. Mitochondria-targeting near-infrared ratiometric fluorescent probe for selective imaging of cysteine in orthotopic lung cancer mice. Sensors and Actuators B: Chemical 2019;282:69-77.
13. Wang Y#, Wang X, Zhang L, Huang Y, Bi L, Lv C, Chen L*. A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment. Journal of Materials Chemistry 2020;8(5):1017-1025.
14. Lu G#, Zhang J#, Liu X, Liu W, Cao G, Lv C, Zhang X, Xu P, Li M*, Song X*. Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis. J Cell Mol Med 2019, 23(10):6720-6729.
15. Zhang J#, Liu H#, Song C#, Zhang J, Wang Y, Lv C*, Song X*. Astilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway. Pulm Pharmacol Ther 2018;50:19-27.
16. Zhao X#, Qu G#, Song C#, Li R, Liu W, Lv C, Song X, Zhang J*, Li M*. Novel formononetin-7-sal ester ameliorates pulmonary fibrosis via MEF2c signaling pathway. Toxicol Appl Pharmacol 2018;356:15-24.
17. Li H#, Wang Z#, Zhang J, Wang Y, Yu C, Zhang J, Song X*, Lv C*. Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway. BMC Complement Altern Med 2018;18(1):234.
18. Liu B#, Li R#, Zhang J#, Meng C, Zhang J, Song X* and Lv C*. MicroRNA-708-3p as a potential therapeutic target via the ADAM17-GATA/STAT3 axis in idiopathic pulmonary fibrosis. Exp Mol Med 2018;50(3):e465.
19. Han X#, Wang R, Song X, Yu F*, Lv C, Chen L*. A mitochondrial-targeting near-infrared fluorescent probe for bioimaging and evaluating endogenous superoxide anion changes during ischemia/reperfusion injury. Biomaterials 2018;156:134-146.
20. Song X#, Han X, Yu F*,Zhang J, Chen L *and Lv C*. A reversible fluorescent probe based on CvN isomerization for the selective detection of form aldehyde in living cells and in vivo. Analyst 2018;143(2):429-439.
21. Song X#, Han X, Yu F*Zhang X, Chen L*, Lv C*. Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy. Theranostics 2018;8(8):2217-2228.
22. Yu Y#, Li W#, Ren L#, Yang C#, Li D, Han X, Sun Y, Lv C* and Han F*. Inhibition of autophagy enhanced cobalt chloride-induced apoptosis in rat alveolar type II epithelial cells. Mol Med Rep 2018;18(2):2124-2132.
23. Li R#, Wang Y#, Song X#, Sun W, Zhang J*, Liu Y, Li H, Meng C, Zhang J, Zheng Q, Lv C*. Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis. Int J Mol Med 2018, 42(6):3256-3268.
24. Ren Y#, Zhao J#, Shi Y, Chen C, Chen X∗, Lv C. Simple determination of L-hydroxyproline in idiopathic pulmonary fibrosis lung tissues of rats using non-extractive high-performance liquid chromatography coupled with fluorescence detection after pre-column derivatization with novel synthetic 9-acetylimidazol-carbazole. J Pharm Biomed Anal 2017;142:1-6.
25. Zhang S#, Liu H#, Liu Y#, Zhang J, Li H, Liu W, Cao G, Xv P, Zhang J, Lv C* and Song X*. miR-30a as Potential Therapeutics by Targeting TET1 through Regulation of Drp-1 Promoter Hydroxymethylation in Idiopathic Pulmonary Fibrosis. Int J Mol Sci 2017;18(3):633.
26. Xu R#*, Yuan Z, Yang L, Li L, Li D, Lv C*. Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress. Oncol Rep 2017;38(3):1767-1773.
27. Liu H#, Wang B#, Zhang J#, Zhang S, Wang Y, Zhang J, Lv C* and Song X*. A novel lnc-PCF promotes the proliferation of TGF-β1-activated epithelial cells by targeting miR-344a-5p to regulate map3k11 in pulmonary fibrosis. Cell Death Dis 2017;8(10):e3137.
28. Gao M#, Yu F*, Lv C, Choo J and Chen L*. Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy. Chem Soc Rev 2017;46(8):2237-2271.
29. Li C#, Yu Y#, Li W, Liu B, Jiao X, Song X, Lv C*, Qin S*. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-Κb signaling pathway. Sci Rep 2017;7(1):5843.
30. Liu H#, Zhao X#, Xiang J#, Zhang J, Meng C, Zhang JLi M, Song X*, Lv C*. Interaction network of coexpressed mRNA, miRNA, and lncRNA activated by TGF-β1 regulates EMT in human pulmonary epithelial cell. Mol Med Rep 2017;16(6):8045-8054.
31. Gao Y#, Zhang J#, Liu Y, Zhang S, Wang Y, Liu B, Liu H, Li R, Lv C*, Song X*. Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis. BMC Pulm Med 2017;17(1):163.
32. Zhao J#, Ren Y#, Qu Y#, Jiang W*, Lv C*. Pharmacodynamic and pharmacokinetic assessment of pulmonary rehabilitation mixture for the treatment of pulmonary fibrosis. Sci Rep. 2017;7(1):3458.
33. Qu Y#, Zhang G#, Ji Y, Zhua H, Lv C*, Jian W*. Protective role of gambogic acid in experimental pulmonary fibrosis in vitro and in vivo. Phytomedicine 2016, 23(4):350-358.
34. Su X#, Wang CWang X, Han F, Lv C*, Zhang X*. Sweet Dream Liquid Chinese Medicine Ameliorates Learning and Memory Deficit in a Rat Model of Paradoxical Sleep Deprivation through the ERK/CREB Signaling Pathway. J Med Food 2016;19(5):472-480.
Research Projects
1. National Natural Science Foundation of China, General Project, 8187001, The Role of lncIAPF-mediated TGFβ1-lncIAPF-HuR-TGFβ1 Positive Feedback Loop and the Action and Mechanism of Action of lncIAPF-HuR EZH2/STAT1 Autophagy Pathway in the Development of Idiopathic Pulmonary Fibrosis, 2019.01-2022.12.
2. National Natural Science Foundation of China, General Project, 81670064, The role of lncITPF on the neighboring gene ITGBL1 and the ceRNA mechanism of target miRNA regulation in idiopathic pulmonary fibrosis, 2017.01-2020.12.
3. National key research and development plan (973 project), 2016YFC1304400, research on the diagnosis and treatment of chronic obstructive pulmonary complications and comorbid diseases, 2016.09-2020.12.
4. National Natural Science Foundation of China, General Project, 31470415, Study on the preparation of formononetin-7-salvianolic acid and its anti-pulmonary fibrosis mechanism, 2015.01-2018.12.
5. International scientific and technological cooperation and exchange special project, 2014DFA31500, the establishment and application research of the home wireless remote diagnosis and treatment system for sleep breathing diseases, 2014.04-2017.04.
6. National Natural Science Foundation of China, General Project, 81273957, The anti-pulmonary fibrosis mechanism of Feifukang Mixture through TGF-β1/Smad3 pathway and related miRNAs, 2013.01-2016.12.
7. Shandong Science and Technology Development Program Project, 2010GWZ20254, establishment of mouse model of pulmonary fibrosis caused by gene mutation and research on pathogenic genes of IPF patients, 2011.01-2013.12.
Academic Employment
Former Member of the Respiratory Branch of the Chinese Medical Doctor Association;
Member of the Interstitial Pulmonary Diseases Group of the Respiratory Branch of the Chinese Medical Association;
Former Vice Chairman of the Respiratory Branch of the Shandong Medical Association;
Former Vice Chairman of the Respiratory Branch of the Shandong Medical Doctor Association;
Former Chairman of the Respiratory Medicine Branch of Binzhou Medical Association.
