Shengtian Zhao, MD, PhD
Professor of Urology
President, Binzhou Medical University
Research Fields
1. Kidney regeneration;
2. Clinical, translational and basic research on urinary and male reproductive system diseases;
3. Prevention and treatment of urinary tract cancer with integrated traditional Chinese and Western Medicine;
4. Hospital management.
Representative Research Papers
1. Han L, Xiang S, Rong B, Liang Y, Zhao S.Verbascoside attenuates experimental varicocele-induced damage to testes and sperm levels through up-regulation of the hypothalamus-pituitary-gonadal (HPG) axis. Pharm Biol. 2021 Dec;59(1):715-722.
2.Guo L, Wu Q, Ma Z, Yuan M, Zhao S. Identification of immune-related genes that predict prognosis and risk of bladder cancer: bioinformatics analysis of TCGA database. Aging (Albany NY). 2021 Jul 30;13(15):19352-19374.
3.Yin L, Zhao H, Zhang H, Li Y, Dong Y, Ju H, Kong F, Zhao S. Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome. Front Immunol. 2021 May 21;12:652446.
4.Xu XH, Xu ZH, Yuan MZ, Guan Y, Zhao ST. Effect of prostate volume on f/tPSA value: A cross-sectional study. Andrologia. 2021 Mar;53(2):e13851.
5.Guo L, Zhao S, Li W, Wang Y, Li L, Jiang S, Ren W, Yuan Q, Zhang F, Kong F, Lei J, Yuan M. Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort. Andrology. 2021 Jan;9(1):42-47.
6.Pan D, Xu ZH, Gao Q, Li M, Guan Y, Zhao ST. Relationship between penile erection and the ratio of estradiol to testosterone: A retrospective study. Andrologia. 2020 Oct;52(9):e13701.
7.Zhang D, Du X, Zhang X, Li K, Kong F, Cheng G, Zhao S. In vitro induction and in vivo engraftment of kidney organoids derived from human pluripotent stem cells. Exp Ther Med. 2020 Aug;20(2):1307-1314.
8.Guo Y, Yuan X, Li K, Dai M, Zhang L, Wu Y, Sun C, Chen Y, Cheng G, Liu C, Strååt K, Kong F, Zhao S, Bjorkhölm M, Xu D. GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer. Cell Death Differ. 2020 Jun;27(6):1862-1877.
9.Li K, Chen Y, Zhang J, Guan Y, Sun C, Li X, Xie X, Zhang D, Yu X, Liu T, Zhang X, Kong F, Zhao S. Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models. Ren Fail. 2020 Nov;42(1):89-97.
10.Wang H, Zhang K, Ruan Z, Sun D, Zhang H, Lin G, Hu L, Zhao S, Fu Q. Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Res Ther. 2020 Jul 21;11(1):302.
11.Xu ZH, Xu XH, Pan D, Liu TY, Yuan MZ, Jiang S, Guan Y, Zhao ST. Effect of estradiol on penile erection: a cross-sectional study. Transl Androl Urol. 2019 Dec;8(6):574-582.
12.Xu ZH, Pan D, Liu TY, Yuan MZ, Zhang JY, Jiang S, Wang XS, Guan Y, Zhao ST. Effect of prolactin on penile erection: a cross-sectional study. Asian J Androl. 2019 Nov-Dec;21(6):587-591.
13.Zhang J, Li K, Kong F, Sun C, Zhang D, Yu X, Wang X, Li X, Liu T, Shao G, Guan Y, Zhao S. Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney. Tissue Eng Regen Med. 2019 Jun 22;16(5):501-512.
14.Qiao Y, Zheng H, Li L, Zhang J, Li Y, Li S, Zhu R, Zhou J, Zhao S, Jiang Y, Lou H. Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca. Bioorg Med Chem. 2018 Aug 7;26(14):4320-4328.
15.Xue A, Niu G, Chen Y, Li K, Xiao Z, Luan Y, Sun C, Xie X, Zhang D, Du X, Kong F, Guo Y, Zhang H, Cheng G, Xin Q, Guan Y, Zhao S. Recellularization of well-preserved decellularized kidney scaffold using adipose tissue-derived stem cells. J Biomed Mater Res A. 2018 Mar;106(3):805-814.
16.Shao G, Liu Y, Ma T, Zhang L, Yuan M, Zhao S. GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1. Biosci Rep. 2018 Nov 30;38(6):BSR20180816.
17.Zheng H, Wu Y, Sun B, Cheng C, Qiao Y, Jiang Y, Zhao S, Xie Z, Tan J, Lou H. Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect. Eur J Med Chem. 2018 Oct 5;158:767-780.
18.Xie X, Du X, Li K, Chen Y, Guan Y, Zhao X, Niu G, Luan Y, Zhang D, Sun C, Cheng G, Wang J, Xin Q, Xue A, Wang P, Kong F, Liu X, Wang H, Liu Y, Tian C, Yuan M, Liu S, Zhao S. Construction of engineered corpus cavernosum with primary mesenchymal stem cells in vitro. Sci Rep. 2017 Dec 22;7(1):18053.
19.Guo L, Liu Y, Wang X, Yuan M, Yu Y, Zhang X, Zhao S. Significance of penile hypersensitivity in premature ejaculation. Sci Rep. 2017 Sep 5;7(1):10441.
20.Huo S, Du W, Shi P, Si Y, Zhao S. The role of spermatogenesis-associated protein 6 in testicular germ cell tumors. Int J Clin Exp Pathol. 2015 Aug 1;8(8):9119-25.
21.Zhou SM, Zhao W, Lin T, Zhao ST, Wang HW. Serum Cystatin C can detect impaired graft function early after renal transplantation. Int J Clin Exp Med. 2015 Sep 15;8(9):16379-83.
22.Guan Y, Liu S, Liu Y, Sun C, Cheng G, Luan Y, Li K, Wang J, Xie X, Zhao S. Porcine kidneys as a source of ECM scaffold for kidney regeneration. Mater Sci Eng C Mater Biol Appl. 2015 Nov 1;56:451-6.
23.Guo L, Sun W, Shao G, Song H, Ge N, Zhao S, Liu Y, Zhang X, Xiao Z, Yuan M. Outcomes of Microscopic Subinguinal Varicocelectomy With and Without the Assistance of Doppler Ultrasound: A Randomized Clinical Trial. Urology. 2015 Nov;86(5):922-8.
24.Qu H, Liu X, Ni Y, Jiang Y, Feng X, Xiao J, Guo Y, Kong D, Li A, Li X, Zhuang X, Wang Z, Wang Y, Chang Y, Chen S, Kong F, Zhang X, Zhao S, Sun Y, Xu D, Wang D, Zheng C. Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells. J Transl Med. 2014 May 20;12:135.
25. Han X, Zhao L, Lu G, Ge J, Zhao Y, Zu S, Yuan M, Liu Y, Kong F, Xiao Z, Zhao S. Improving outcomes of acute kidney injury using mouse renal progenitor cells alone or in combination with erythropoietin or suramin. Stem Cell Res Ther. 2013 Jun 18;4(3):74.
Research Projects
1. National Natural Science Fund, General Program, 81970578, Research on mechanism of FGF9/Wnt pathway in the differentiation of IPSC in kidney decellularized scaffold, 01/01/2020-12/31/2023
2. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Academic Promotion Program, 2020LI001, The application and mechanism of stem cells in renal regeneration and sexual function repair, 07/01/2019-06/31/2024
3. National Natural Science Fund, General Program, 81670625, Research on mechanism of inducing iPSC to construct kidney-like tissues with regional biological scaffold in vitro, 01/01/2016-12/31/2019
4. National Natural Science Fund, General Program, 81470969, Study of Bioengineered Kidney with Decellularized Scaffold of Large Animals, 01/01/2015-12/31/2018
5. National Natural Science Fund, General Program, 81272815, Study the molecular markers and biological characters of the renal cancer stem cell, 01/01/2013-12/31/2013
6. Science Foundation for the National Natural Science Chair Research, 81041065, The study of cancer stem cells for renal cell carcinoma, 01/01/2011-12/31/2011
Academic Employment
Executive Director of the Chinese Medical Doctor Association;
Executive Director of the Chinese Hospital Association;
Vice Chairman of the Andrology and Sexual Medicine Physician Branch of the Chinese Medical Doctor Association;
Former Chairman of the Urology Branch of the Shandong Medical Doctor Association;
Chairman of the Shandong Provincial Hospital Association, President of the World Chinese Andrologist Associationt, etc.
