Qin Yue, PhD, Professor
Chief Scientist of Project 973, Ministry of Science and Technology of China.
Director, Peninsula Cancer Center, Binzhou Medical University
Research Fields
1. Identify the apparent post-translational modification profile of the protein;
2. R&D of small molecule drugs targeting PD-1 and SHP-2/STAT immune nodes;
3. R&D of circulating tumor cell (CTC) diagnosis and dialysis technology;
4. the mechanism of lung cancer occurrence and lung cancer metastasis.
Representative Research Papers
1.Shen J, Hu L, Yang L, Zhang M, Sun W, Lu X, Lin G, Huang C, Zhang X, Chin YE. Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation. Signal Transduct Target Ther. 2020;5:115. doi: 10.1038.
2.Zhang YS, Xin DE, Wang Z, Song X, Sun Y, Zou QC, Yue J, Zhang C, Zhang JM, Liu Z, Zhang X, Zhao TC, Su B, Chin YE.STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO J. 2019;38:e99595.
3.Huang C, Zhang Z, Chen L, Lee HW, Ayrapetov MK, Zhao TC, Hao Y, Gao J, Yang C, Mehta GU, Zhuang Z, Zhang X, Hu G, Chin YE. Acetylation within the N- and C-Terminal Domains of Src Regulates Distinct Roles of STAT3-Mediated Tumorigenesis. Cancer Res. 2018;78:2825-2838.
4.Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell. 2017 ;65:296-309.
5.Zhong S, Yin H, Liao Y, Yao F, Li Q, Zhang J, Jiao H, Zhao Y, Xu D, Liu S, Song H, Gao Y, Liu J, Ma L, Pang Z, Yang R, Ding C, Sun B, Lin X, Ye X, Guo W, Han B, Zhou BP, Chin YE*, and Deng J*. Lung tumor suppressor GPRC5A binds EGFR and restrains its effector signaling. Cancer Res, 75(9):1801-14, 2015
6.Tang X, Gao JS, Guan YJ, McLane KE, Yuan ZL, Ramratnam B, Chin YE. Acetylation-dependent signal transduction for type I interferon receptor. Cell. 2007;131: 93-105.
7.Yuan ZL, Guan YJ, Chatterjee D, Chin YE. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005;307:269-73.
8.Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y, Fu XY. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science. 1996; 272:719-22.
Research Projects
1. Project 973 of Ministry of Science and Technology of China, Chief Scientist, Posttranslational Modifications of Lysine Residues and Protein Function, 2013CB910900,01/2013-08/2017.
2. National Science Foundation of China, Key Project, eSIRT2 micro-environment metabolism regulation mechanism and anti-tumor metastasis of targeted eSIRT2, 01/2021-12/2025.
3. National Science Foundation of China, International (Regional) Cooperation and Exchanges Project, 81820108023, The new function of lysine oxidase: deacetylation and deaminoacetylation and the effect mechanism in the occurrence and development of genital system tumors ,01/01/2019-12/31/2023.
4. National Science Foundation of China, Key Project of International Cooperation, 81530083, Adjustment of cancer stem cell metastasis by STAT3 and Sec15 exosome micro-vesicle formation and secretion, 01//01/2016-12/31/2019.
5. National Science Foundation of China, Function and mechanism study on metabolic disorder in leukemia inhibitory factor receptor(LIFR) of acetylation mediation in breast cancer, 01/01/2013-12/31/2017.
Academic Employment
former Chief Editor of Caner Cell International; Member of Editorial Board of Journal of Biological Chemistry, Current Chemical Biology and eLS (www.els.net); Contributing Writer of Cell.
