On December 7, The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice written together by the Aging Medicine Research Team of our university and the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, was online published on Nature Metabolism.
Based on effective interventions for body aging and aging-related diseases, the research screened out a large number of anti-aging natural source substances, and identified several candidate compounds, including grape seed extracts. Further analysis showed that the flavonoid procyanidin C1 (PCC1 for short) is an important component of GSE,which can selectively induce apoptosis in senescent cells. Preclinical data shows that the combination of PCC1 and classic chemotherapy can significantly reduce the size of tumor and prolong the survival time of experimental animals. Besides, for mice after irradiation, with senescent cell implantation or naturally aging cells, PCC1 can effectively reduce their physiological dysfunction and Significantly prolong its survival period.
As an anti-aging candidate drug, PCC1 can be used to delay aging and reduce age-related diseases. The team will then further explore its clinical value in geriatrics.
The research was supported by the Ministry of Science and Technology, the National Natural Science Foundation of China, the Chinese Academy of Sciences, Yantai School-Local Integration Project and Yantai Double Hundred Talents Program.
BY: Fu Qiang
SOURCE: School of Pharmacy (Wine School)
