Li Bo, PhD, Lecturer
Faculty Member of School of Special Education
Research Fields
Research on the mechanism of hearing loss & balance disorder and its intervention methods, including genetic deafness, noise deafness, deafness caused by ototoxic drugs, otitis media, presbycusis deafness and cognitive impairment and vestibular balance disorder.
Representative Research Papers
1. Bo Li, John C Reed, Hyung-Ryong Kim, Han-Jung Chae. Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice. Molecules and cells. 2012, 34(1):15-23.
2. Do-Sung Kim#, Bo Li#, Ki Yon Rhew, Hyo-Won Oh, Hyun-Dae Lim, Wan Lee, Han-Jung Chae, Hyung-Ryong Kim. The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts. Archives of pharmacal research. 2012, 35(7):1269-1278.
3. Bo Li, Do-Sung Kim, Hyo-Won Oh, Hyun-Dae Lim, Wan Lee, Ki Yon Rhew, Hyung-Ryong Kim, Han-Jung Chae. N-Nitrosodimethylamine induced lung fibroblast cell death is associated with JNK activation. Molecular & Cellular Toxicology. 2012, 8(2):155-161.
4. Chang-Feng Jin#, Bo Li#, Shun-Mei Lin, Raj-Kumar Yadav, Hyung-Ryong Kim, Han-Jung Chae. Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4 -Induced Acute Liver Lipid Accumulation in Rats. International journal of endocrinology. 2013, 2013:751854.
5. Bo Li, Raj Kumar Yadav, Hyung-Ryong Kim, Han-Jung Chae. The characteristics of Bax inhibitor-1 and its related diseases. Current molecular medcine. 2014, 14(5):603-15.
6. Geum-Hwa Lee, Hwa-Young Lee, Bo Li, Hyung-Ryong Kim, Han-Jung Chae. Bax inhibitor-1-mediated inhibition of mitochondrial Ca2+ intake regulates mitochondrial permeability transition pore opening and cell death. Scientific reports. 2014, (5)4:5194.
7. Raj Kumar Yadav, Geum-Hwa Lee, Hwa-Young Lee, Bo Li, Han-Eul Jung, Harun-Or Rashid, Min Kyung Choi, Binod Kumar Yadav, Woo-Ho Kim, Kyung-Woon Kim, Byung-Hyun Park, Won Kim, Yong-Chul Lee, Hyung-Ryong Kim, Han-Jung Chae. TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model. Autophagy. 2015;11(10):1760-74.
8. Bo Li#, Do Sung Kim#,Raj Kumar Yadav, Hyung Ryong Kim*, Han Jung Chae*. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. International journal of molecular medicine. 2015; 36(1):53-64.
9. Juan Hu, Bo Li, Luke Apisa, Heping Yu, Shami Entenman, Min Xu, Ruben Stepanyan, Bo-Jhih Guan, Ulrich Müller, Maria Hatzoglou, Qing Yin Zheng*. ER stress inhibitor attenuates hearing loss and hair cell death in Cdh23erl/erl mutant mice. Cell death & disease. 2016;7(11):e2485.
10. Bo Li#, Tihua Zheng#, Caifang Yan#, Wenjun Wang, Jinjin Zhang, Luping Zhang, Juan Hu, Li Zhang, Yuzhu Wan, Minyan Zhang, Qingyin Zheng*, Chemical chaperone 4-phenylbutyrate prevents hearing loss and cochlear hair cell death in Cdh23erl/erl mutant mice. Neuroreport. 2019, 30(3):145-150.
11. Tong Zhao#, Xiuzhen Liu#, Zehua Sun#, Jinjin Zhang, Xiaolin Zhang, Caoyun Wang, Ruishuang Geng, Tihua Zheng*, Bo Li*, Qing Yin Zheng, RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model. Aging-US. 2020, 12(8): 7491-7510.
12. Tong Zhao#, Tihua Zheng#, Huining Yu#, Bo Hua Hu, Bing Hu, Peng Ma, Ying Yang, Naidi Yang, Juan Hu, Tongtao Cao, Gang Chen, Bin Yan, Melina Peshoff, Maria Hatzoglou, Ruishuang Geng*, Bo Li*, Qing Yin Zheng. Autophagy impairment as a key feature for acetaminophen-induced ototoxicity. Cell Death & Disease. 2021, 4;12(1):3.
13. Tong Zhao#, Peng Ma#, Fangfang Zhao#, Tihua Zheng, Bin Yan, Qiang Zhang, Jing Yuan, Bing Hu, Ying Yang, Juan Hu, Ruishuang Geng, Bo Hua Hu, Tengyang Sun, Qing Yin Zheng*, Bo Li*. Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene. Journal of Neuroscience Research. 2021, 99(10):2743-2758.
Research Projects
1. National Natural Science Fund, Youth Program, 81400467, Endoplasmic reticulum stress is involved in hearing impairment in cdh23erl/erl mice, 01/01/2015-12/31/2017;
2. National Natural Science Fund, General Program, 81873697, Role of autophagy impairment in the otitis media induced by peptidoglycan-polysaccharide in TLR2-deficient mice, 01/01/2019-12/31/2022.
