Wang Chunhua, PhD, Professor
Dean, School of Pharmacy
Research Fields
1. Research and development of medical antibacterial materials;
2. Drug synthesis and activity evaluation;
3. Screening and evaluation of natural drug active ingredients.
Representative Research Papers
1. Wei Cong, Yue Sun, Yi-Fan Sun, Wei-Bin Yan, Yu-Long Zhang, Zhong-Fei Gao, Chun-Hua Wang, Gui-Ge Hou & Jia-Jing Zhang. Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-кB activation. J Enzyme Inhib Med Chem. 2021;36(1):1622-1631.
2. Yue Sun, Zhong-Fei Gao, Wei-Bin Yan, Bin-Rong Yao, Wen-Yu Xin, Chun-Hua Wang, Qing-Guo Meng, Gui-Ge Hou*, Discovery of novel NF-кB inhibitor based on scaffold hopping: 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine. Eur J Med Chem，2020,198, 112366.
3. Yao BR, Sun Y, Chen SL, Suo HD, Zhang YL, Wei H, Wang CH*, Zhao F, Cong W, Xin WY*, Hou GG*. Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4- piperidones as anti-hepatoma agents by inhibiting NF-кB pathway activation. Eur J Med Chem, 2019, 167: 187-199.
4. Xianrui Xie, Dongsheng, Changming Su, Wei Cong, Xiumei Mo, Guige Hou∗, and Chunhua Wang∗. Functionalized biomimetic composite nanfibrous scaffolds with antibacterial and hemostatic efficacy for facilitating wound healingJ Biomed Nanotechnol, 2019, 15, 1267-1279.
5. Ning Li, Wen-Yu Xin, Bin-Rong Yao, Wei Cong, Chun-Hua Wang*, Gui-Ge Hou*. N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-kB inhibitors in hepatic carcinoma cell lines. European Journal of Medicinal Chemistry, 2018, 155, 531-544.
6. Ning Li, Wen-Yu Xin, Bin-Rong Yao, Chun-Hua Wang, Wei Cong, Feng Zhao, Hong-Juan Li, Yun Hou, Qing-Guo Meng*, Gui-Ge Hou*. Novel asymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo. European Journal of Medicinal Chemistry, 2018, 147, 21-33.
7. Xianrui Xie, Wei Cong, Feng Zhao, Hongjuan Li, Wenyu Xin, Chunhua Wang*, Gui-Ge Hou*, Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts. J Enzyme Inhib Med Chem. 2017, 33(1):98-105.
8. Chun-Hua Wang*, Xian-Rui Xie, Wen-Shuai Liu, Gui-Ge Hou*, Ju-Feng Sun, Feng Zhao, Wei Cong, Hong-Juan Li, Wen-Yu Xin, Quaternary ammonium salts substituted by 5-phenyl-1,3,4-oxadiazole-2-thiol as novel antibacterial agents with low cytotoxicity. Chemical Biology & Drug Design, 2017, 90(5), 943-952.
9. Chun-Hua Wang*, Wen-Shuai Liu, Ju-Feng Sun, Gui-Ge Hou*, Qin Chen, Wei Cong, Feng Zhao, Non-toxic O-quaternized chitosan materials with better water solubility and antimicrobial function, International Journal of Biological Macromolecules, 2016, 84, 418-427.
10. Qin Chen, Yun Hou, Gui-Ge Hou*, Ju-Feng Sun, Ning Li, Wei Cong, Feng Zhao, Hong Juan Li, Chun-Hua Wang*. Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone derivatives. Research on Chemical Intermediates, 2016, 42(12): 8119-8130.
Research Projects
1. Key Science and Technology Innovation Project of Shandong Province, 2019JZZY011104, R&D and demonstration of key technology of medical wound repair material composite, 01/01/2019-12/31/2021.
2. Key RESEARCH and Development Project of Yantai city, 2019XDHZ108, Research on the pharmacodynamic substance baseline of qiang huo sheng shi Decoction , 01/01/2019-12/31/2021.
3. Shandong Province Independent Innovation and Achievement Transformation Special Project, 2014CGZH1316, Research and development of high Value-added Marine biological products sea urchin polysaccharide, 01/01/2014-12/31/2017.
4. Key Research and Development Project of Shandong Province, 2015GGX102013, Preparation and properties of quaternized chitosan/collagen electrospinning hemostatic membrane, 01/01/2016-12/31/2017.
5. Natural Science Foundation of Shandong Province, ZR2013BM022, Synthesis and antibacterial properties of N-heterocyclic O-substituted chitosan quaternary ammonium salt and 5-Fu drug loading application, 01/01/2014-12/31/2016.
6. Yantai Science and Technology Development Project, 2013ZH095, O-long chain alkyl chitosan and quaternary ammonium salt preparation and antibacterial activity, 01/01/2013-12/31/2015.
7. Yantai Key Research and Development Program, 2016ZH078, High throughput screening and macroporous resin separation technology in the secondary development of Runfei ointment, 01/01/2016-12/31/2018.
Academic Employment
Member of expert Committee of Antibacterial Industry Branch of National Health Industry Enterprise Management Association;
Standing Director of Shandong Pharmaceutical Biotechnology Association;
Director of the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China;
Director of Shandong Provincial Traditional Chinese Medicine Scientific Research Key Laboratory of Traditional Chinese Medicine Modernization and New Formulation Development.
