Hou Guige, PhD, Professor
Deputy Dean, School of Pharmacy
Research Fields
1. Research and development of medical antibacterial materials;
2. Drug synthesis and activity evaluation.
Representative Research Papers
1. Cheng-Long Gao#, Gui-Ge Hou#, Jin Liu#, Tong Ru, Ya-Zhou Xu, Shun-Yi Zhao, Hui Ye, Lu-Yong Zhang, Kai-Xian Chen, Yue-Wei Guo,* Tao Pang,* and Xu-Wen Li*. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. Angew. Chem. Int. Ed. 2020, 59: 2429-2439.
2. Yan-Qiu Zhou, Yue Sun, Han-Lin Luo, Zhong-Fei Gao, Hong-Qin Zhang, Qing-Guo Meng, Xian-Yong Bai *, Gui-Ge Hou *, Yun Hou *. Discovery of anti-hepatoma agents from 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine by inhibiting PI3K/AKT/NF-kB pathway activation. European Journal of Medicinal Chemistry, 2021, 225: 113796.
3. Yue Sun, Zhong-Fei Gao, Wei-Bin Yan, Bin-Rong Yao, Wen-Yu Xin, Chun-Hua Wang, Qing-Guo Meng, Gui-Ge Hou*, Discovery of novel NF-кB inhibitor based on scaffold hopping: 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine. Eur J Med Chem, 2020, 198: 112366.
4. Yao BR, Sun Y, Chen SL, Suo HD, Zhang YL, Wei H, Wang CH*, Zhao F, Cong W, Xin WY*, Hou GG*. Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-кB pathway activation. Eur J Med Chem, 2019, 167: 187-199.
5. Ning Li, Wen-Yu Xin, Bin-Rong Yao, Chun-Hua Wang, Wei Cong, Feng Zhao, Hong-Juan Li, Yun Hou, Qing-Guo Meng*, Gui-Ge Hou*. Novel asymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo. European Journal of Medicinal Chemistry, 2018, 147: 21-33.
6. Ning Li, Wen-Yu Xin, Bin-Rong Yao, Wei Cong, Chun-Hua Wang*, Gui-Ge Hou*. N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-kB inhibitors in hepatic carcinoma cell lines. European Journal of Medicinal Chemistry, 2018, 155: 531-544.
7. Xianrui Xie, Wei Cong, Feng Zhao, Hongjuan Li, Wenyu Xin, Chunhua Wang*, Gui-Ge Hou*, Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts. J Enzyme Inhib Med Chem. 2017, 33(1): 98-105.
8. Lianshuang Zhang, Qin Chen, Guige Hou*, Wei Zhao and Yun Hou*. Hydroxyl-substituted double Schiff-base condensed 4-piperidone/cyclohexanones as potential anticancer agents with biological evaluation. J Enzyme Inhib Med Chem. 2019, 34: 264-271.
9. Xianrui Xie, Dongsheng, Changming Su, Wei Cong, Xiumei Mo, Guige Hou∗, and Chunhua Wang∗. Functionalized biomimetic composite nanfibrous scaffolds with antibacterial and hemostatic efficacy for facilitating wound healing. J Biomed Nanotechnol, 2019, 15: 1267-1279.
10. Chun-Hua Wang, Wen-Shuai Liu, Ju-Feng Sun, Gui-Ge Hou∗, Qin Chen, Wei Cong, Feng Zhao. Non-toxic O-quaternized chitosan materials with better watersolubility and antimicrobial function. Int J Biolog Macromol, 2016, 84: 418-427.
11. Gui-Ge Hou, Yue Liu, Qi-Kui Liu, Jian-Ping Ma and Yu-Bin Dong*. NbO lattice MOFs based on octahedral M(II) and ditopic pyridyl substituted diketonate ligands: structure, encapsulation and guest-driven luminescent property. ChemComm. 2011, 47: 10731-10733.
12. Gui-Ge Hou, Jian-Ping Ma, Ting Sun, Yu-Bin Dong*, and Ru-Qi Huang. A binuclear CuII metallacycle capable of discerning between pyrazine and its different methyl-substituted derivatives based on reversible intracage metal-ligand binding. Chem. Eur. J., 2009, 15: 2261-2265.
Research Projects
1. Shandong Provincial Natural Science Fund, ZR2019MB032, Chiral resolution of a novel hexahydropyridino [4,3-d] pyrimidine derivative and its mechanism of inhibition of NF-κB signaling pathway in liver cancer, 01/07/2019-06/30/2022.
2. Science and Technology Support Project of Shandong University Innovation Team, 2020KJK003, Wound repair materials Research and development innovation team: Preparation and properties of wound dressing based on electrostatic spinning Technology, 01/01/2020-12/31/2022.
3. National Natural Science Fund, 21402010, Directional synthesis and antitumor activity of M2L2 Water-soluble metal-drug Complex, 01/01/2014-12/31/2017.
4. Key Research and Development Project of Yantai city, 2018XSCC048, preparation of composite electrospun fiber membrane and development of scar repair performance, 01/01/2018-12/31/2020.
5. The Major Science and Technology Innovation Project of Shandong Province, 2019JZZY011104, Research and development and demonstration of key technology of medical wound repair material composite, 01/01/2019-12/31/2021. (The second place)
6. Special Discipline Project of Yantai Schools and the Local Integration Project, provincial first-class pharmacy specialty construction under medical background, 01/01/2021-09/30/2023.
Academic Employment
Director of Yantai Pharmaceutical Association;
Director of Shandong Medical Biotechnology Society;
Member of Higher Pharmaceutical Education Committee, Shandong Pharmaceutical Association;
Reviewer of Eur J Med Chem, Chem Biol Drug Des, Mini-Rev Med Chem, etc.
