Jing Chen, PhD, Professor
Leader of Shandong University Youth Innovation Team
Research Fields
1. Application of controllable nanomedicine in response to tumor microenvironment in cancer diagnosis and treatment;
2. Tumor hypoxic microenvironment adaptive treatment tolerance.
Representative Research Papers
1. Chen J, Wang X, et al. Exploiting the acquired vulnerability of cisplatin-resistant tumors with a hypoxia-amplifying DNA repair–inhibiting (HYDRI) nanomedicine[J]. Science Advances, 2021, 7: eabc5267.
2. Chen J, Liu L, et al. Light‐Triggered Retention and Cascaded Therapy of Albumin‐Based Theranostic Nanomedicines to Alleviate Tumor Adaptive Treatment Tolerance[J]. Advanced Functional Materials, 2018, 28: 1707291.
3. Zhang J, Chen J, et al. Biocompatible semiconducting polymer nanoparticles as a robust photoacoustic and photothermal agent revealing the effects of chemical structure on high photothermal conversion efficiency[J]. Biomaterials, 2018, 181: 92-102.
4. Hu J, Guan Z, Chen J*. Multifunctional biomaterials that modulate oxygen levels in the tumor microenvironment[J]. Cancer Letters, 2021, 521: 39-49.
5. Guo W, Chen J, et al. Laser Induced Transformable BiS@HSA/DTX Multiple Nanorods for Photoacoustic/Computed Tomography Dual-Modal Imaging Guided Photothermal/Chemo Combinatorial Anticancer Therapy[J]. ACS Applied Materials & Interfaces, 2018, 10: 41167–41177.
6. Chen J, Zhao M, et al. Synthesis of reduced graphene oxide intercalated ZnO quantum dots nanoballs for selective biosensing detection[J]. Applied Surface Science, 2016, 376: 133-137.
7. Chen J, Zhao M, et al. Preparation of graphene oxide/multiwalled carbon nanotubes 3D flexible architecture for robust biosensing application[J]. Ceramics International, 2015, 41(10): 15241-15245. (第一作者, IF=2.88, 二区)
Research Projects
1. National Natural Science Fund, Youth Program, 82102209, Construction of intracellular hypoxia programmably activated nanotherapy system based on hypoxia in cisplatin-resistant tumor cells，01/01/2022-12/31/2024.
2. Shandong University Youth Innovation Team, Talents Introduction and Cultivation Program, 2019-063, Chemical Biology Research Innovation Team, 09/01/2019-08/31/2022.
