Ma Lei, MD, Professor of Medicine
Research Fields
Molecular immune mechanism of psoriasis
Representative Research Papers
1. Miao Mengyu, Ma Lei (T). The efficacy and safety of JAK Inhibitors for Atopic Dermatitis: a systematic review and meta-analysis[J]. J Dermatolog Treat. 2021 Jun 16;1-28.
2. Wang Yanqin, Li Xinxin, Xing Xiaoyun, Xue Haibo, Qi Ruiqun, Ji Hong, Ma Lei (T). Notch-Hes1 Signaling Regulates IL-17A+γδ+T Cell Expression and IL-17A Secretion of Mouse Psoriasis-Like Skin Inflammation[J]. Mediators of inflammation. 2020, 2020: 8297134.
3. Du X, Li R, Song S, Ma L(T), Xue H. The Role of MIF-173G/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases[J]. Mediators of Inflammation. 2020, 2020: 7825072.
4. Ma L, Xue H, Qi R, Wang Y, Yuan L. Effect of γ-Secretase Inhibitor on Th17 Cell Differentiation and Function of Mouse Psoriasis-like Skin Inflammation[J]. Journal of Translational Medicine. 2018, 16:59.
5. Ma L, Xue H, Gao T, Gao M, Zhang Y. Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris[J]. Mediators of Inflammation. 2018, 2018: 3069521.
6. Ma L, Xue HB, Wang F, Shu CM, Zhang JH. MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells. Clin Exp Immunol. 2015 Jul;181(7):142-9.
7. Ma L, Wang M, Wang X, Chen X, Zhu X. Circulating IgE anti-BP180 autoantibody and its correlation to clinical and laboratorial aspects in bullous pemphigoid patients. J Dermatol Sci. 2015 Apr;78(1):76-7.
8. Ma L, Xue HB, Guan XH, Shu CM, Zhang JH, Yu J. Clinical and Experimental Immunology. 2014 Jan;175(1):25-31.
9. Ma L, Xue HB, Guan XH, Shu CM, Wang F, Zhang JH, An RZ. The Imbalance of Th17 cells and CD4+CD25highFoxp3+ Treg cells in patients with atopic dermatitis. J Eur Acad Dermatol Venereol. 2014 Aug;28(8):1079-86.
10. Ma L, Xue HB, Guan XH, Shu CM, Zhang YJ, Zhang JH, An RZ. Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris. Braz J Med Biol Res. 2013 May; 46(5): 460-4.
11. Ma L, Xue HB, Guan XH, Qi RQ, Liu YB. Macrophage migration inhibitory factor promoter 173G/C polymorphism is associated with atopic dermatitis risk. Int J Dermatol. 2014 Jan;53(1):e75-7.
12. Ma L, Xue HB, Guan XH, Qi RQ, An RZ, Shu CM, Zhang YJ, Wei YH, Zhang JH. Possible role of Th17 cells and IL-17 in the pathogenesis of atopic dermatitis in northern China. J Dermatol Sci. 2012 Oct;68(1):66-8.
13. Ma L, Zhang L, Di ZH, Zhao LP, Lu YN, Xu J, Chen HD, Gao XH. Association analysis of filaggrin gene mutations and atopic dermatitis in Northern China. Br J Dermatol. 2010 Jan;162(1):225-7.
14. Ma L, Gao XH, Zhao LP, Di ZH, Mchepange UO, Zhang L, Chen HD, Wei HC. Brain-derived neurotrophic factor gene polymorphisms and serum levels in Chinese atopic dermatitis patients. J Eur Acad Dermatol Venereol. 2009 Nov;23(11):1277-81.
15. Ma L, Zheng S, Gao XH. Rapid onset of squamous cell carcinoma in a short-standing lichen sclerosus et atrophicus of the penis. Chin Med J (Engl). 2009 Mar 5;122(5):591-2.
Research Projects
National Natural Science Fund, 81803145, Notch1/Hes1-IL17A positive feedback loop promotes Th17 cell differentiation to mediate the pathogenesis of psoriasi, 01/01/2019-12/31/2021.
Academic Employment
Member of Chinese Dermatologist Association;
Member of Therapeutics of Chinese Society of Dermatology;
Member of Shandong Provincial Dermatologist Association;
Member of Shandong Provincial Society of Dermatology.
