Jia Xiuhong, MD, Professor
Research Fields
Pathogenesis and treatment of childhood leukemia
Representative Research Papers
1.Wang H,Jia XH,Chen JR,et al,HOXB4 knockdown reverses multidrug resistance of humanmyelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. Int J Oncol, 2016, 49 (6): 2529-2537. IF: 3.079
2.Chen JR,Jia XH, Wang H,Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3/Aktsignaling pathway. Int J Oncol, 2016, 48 (5): 2063-2070. IF: 3.079
3.Chen JR,Jia XH,Wang H,et al.With no interaction, knockdown of Apollon and MDR1 reverse the multidrug resistance of humanchronic myelogenous leukemia K562/ADM cells. Oncol Rep, 2017, 37 (5): 2735-2742. IF: 2.662
4.Wang H, Jia XH, Chen JR,et al.Osthole shows the potential to overcome P-glycoprotein-mediated multidrug resistance in human myelogenous leukemia K562/ADM cells by inhibition the PI3K/Akt signaling pathway. Oncol Rep, 2016, 35 (6): 3659-3668. IF:2.662
5.Yi YJ, Jia XH, Wang JY, et al. Knockdown of HOXA10 reverse the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1. Int J Mol Med, 2016, 37 (5): 1405-1411. IF:2.341
6.Li N,Jia XH,Wang J,et al. Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells. Mol Med Rep, 2015, 12 (5): 6861-6866. IF:1.692
7.Wang JY, Jia XH, Xing HY, et al, Inhibition of Forkhead box protein M1 by thiostrepton increases chemosensitivity to doxorubicin in T-cell acute lymphoblastic leukemia. Molecular Medicine Reports. 2015, 12 (1): 1457-1464. IF:1.692
8.Yi YJ, Jia XH, Zhu C, et al. Solanine reverses multidrug resistance in human myelogenous leukemia K562/ADM cells by downregulating MRP1 expression. Oncol Lett. 2018, 15 (6): 10070-10076. IF:1.664
9.Yi YJ, Jia XH, Wang JY, et al. Solanine induced apoptosis and increased chemosensitivity toAdriamycin in T-cell acute lymphoblastic leukemia cells. Oncol Lett. 2018, 15 (5): 7383-7388. IF:1.664.
Research Projects
1. Natural Science Foundation of Shandong Province，General Program，HR2014HL032，Expression and significance of homolobox gene (Hox)A10 in childhood acute leukemia, 12/2014-12/2017.
2. Shandong Province Medical and health science and Technology Development Plan, General Program, 2014WS0183, Molecular mechanism of targeting Apollon gene silencing to reverse multidrug resistance in leukemia K562/ADM cells, 11/2014-12/2016.
Scientific research reward
1. The third prize of Science and Technology Award of Shandong Universities, Molecular mechanism of targeting Silencing Apollon gene to reverse multidrug resistance of leukemia K562/ADM cells, 2018.10
2. The third prize of Shandong Medical Science and Technology Innovation Achievement Award, Molecular mechanism study of HOXA10 gene targeted silencing combined with ligustrazine to reverse multidrug resistance of leukemia cells, 2017.12
3. Third prize of Excellent Scientific Research Achievement Award of Shandong Universities, Effect of targeted homolobox genes HOXA9 and HOXA10 on transplanted leukemia in immunodeficient mice, September 2014
4. The Second prize of Shandong University Excellent Scientific Research Achievement Award, Study on the expression and significance of homologous box gene HOXA10 in childhood acute leukemia, 2013.09
5. The third prize of Outstanding Scientific and technological Innovation Achievement Award of Shandong Graduate students，Construction of specific eukaryotic expression vector targeting HOXA10 and its effect on K562 cells, 2012.05
Academic Employment
Committee member of Pediatrics, Higher Education Steering Committee, Ministry of Education;
Member of Shandong Medical Teaching Steering Committee;
Leader of pediatrics of First-class curriculum in Shandong Province;
Chairman of pediatric Professional Committee of Binzhou Medical Association;
Director of Binzhou Pediatric Quality Control Center. etc.
