Recently, Qi Xiangyu, a 2019 graduate student of BMU, published a high quality academic paper as the first author Transferrin Protein Corona Modified CuGd core-shell Nanoplatform for tumor-targeting Photothermal and Chemodynamic Synergistic Therapies in top journal of American Chemical Society ACS Applied Materials & Interfaces (CAS Area 1, IF: 9.229). This paper is a new achievement of tumor targeted therapy by the Molecular Targeted Intelligent Diagnosis and Treatment Technology Innovation Center of our University.
Photothermal therapy is an effective noninvasive treatment strategy for cancer. Since tumor cells are more sensitive to temperature changes than normal cells, photothermal therapy can effectively ablate tumor tissue while avoiding damage to normal tissue. Chemodynamic therapy uses fenton in situ or fenton-like reactions to produce highly toxic hydroxyl radicals that in turn cause cancer cell death. In this study, a novel transferrin modified copper gadolinium core-shell nanoparticles were designed for tumor targeted photothermal and chemodynamic co-therapy. The nanoparticles not only improved its tumor inhibition ability, but also significantly limited the continued growth of tumors after discontinuation of treatment. The nanoparticles significantly enhanced the T1-weighted signal of tumors, achieving accurate cancer diagnosis. The design concept of copper-based nanoplatform for tumor targeted chemodynamics and photothermal therapy has been enriched.
The research was supported by the National Natural Science Foundation of China, the Central Guiding Local Special Funds and the Major Basic Projects of The Natural Science Foundation of Shandong Province. Shandong Molecular Targeted Intelligent Diagnosis and Treatment Technology Innovation Center of Binzhou Medical University is the exclusive unit for the completion of this result.
Link of the Paper: https://pubs.acs.org/doi/10.1021/acsami.1c22998
SOURCE: Graduate School
BY: Hu Wei
