On June 13th, BMU published an academic paper Sustainable Production of Astaxanthin in Microorganisms: the Past, Present, and Future on the international journal of food and nutrition Critical Reviews in Food Science and Nutrition (IF: 11.176) as the first signature unit. Professor Meng Chunxiao as the first author, is from the Microbial Metabolic Engineering and Efficient Utilization Team of the School of Pharmacy (School of Wine), and Professor Guanquan Gao is the corresponding author. The team published a paper titled Cytochrome P450s in Algae: Bioactive Natural Product Biosynthesis and Light-driven Bioproduction in the professional journal of pharmacology, toxicology and pharmacy Acta Pharmaceutica Sinica B（IF: 11.413）, with Professor Meng Chunxiao as the co-corresponding author, Professor Gao Quanquan participating in the research and an author of the paper, and BMU as the co-corresponding unit of the paper.
In Sustainable Production of Astaxanthin in Bombardment: The Past, Present, and Future, it is pointed out that astaxanthin is the strongest antioxidant found in nature and has a very broad application prospect in medicine, food, cosmetics and aquaculture. In this paper, it discusses the key enzymes in the synthetic pathway and their roles in metabolism, and summarizes the traditional, non-genetic strategies for astaxanthin production, including exogenous additives, mutagenesis and adaptive evolution. Typical successful cases of astaxanthin synthesis in various recombinant microorganisms based on the concept of microbial cell factory are emphatically described. In addition, several new techniques for improving astaxanthin accumulation in model microorganisms have been proposed, and these innovative strategies have been comprehensively evaluated to explore the potential of further increasing astaxanthin production. This paper provides a new perspective for related industries and researchers.
Figure 1. Astaxanthin Biosynthesis Pathways in Algae, Yeast and Bacteria
Figure 2. Traditional, Current and Future Strategies for Astaxanthin Production
Figure 3. Combined Application of Innovative Strategies to Increase Astaxanthin Production
Link of the Paper: https://www.tandfonline.com/doi/full/10.1080/10408398.2022.2080176
According to Cytochrome P450s in algae: Bioactive Natural Product Biosynthesis and Light-Driven Bioproduction, algae, in order to adapt to the needs of various growth environments, can metabolize and produce a variety of natural products, such as polyketones, non-ribosomal peptides, terpenoids and alkaloids, which can be used for the development of anticancer, antiviral and antibacterial clinical drugs. Algal cytochrome P450 enzyme plays an important role in the synthesis of these natural compounds, but the mechanism of action is very limited. In this paper, the importance of algae P450 enzymes, and the catalytic mechanism in the biosynthesis of natural products and drugs in biological manufacturing is reviewed in detail, and the theoretical and technical feasibility of drive of heterologous P450 reaction is discussed. Finally, the use of algae as drive cell factories implementation of green manufacturing drugs/chemicals in the problems and challenges is analyzed, and the future research and development direction are also prospected. This paper provides a new idea for the research of using P450 enzyme to efficiently synthesize drugs and high-value chemicals by using microalgae, which is a non-traditional microorganism for photosynthesis and carbon fixation, as the substrate.
Figure 1. Main Types of Algae P450 and Their Common Catalytic Cycles
Figure 2. Algal Photosynthesis Pathways and Their Use as Electron Donors to Drive Heterologous P450 Reactions
Figure 3. Biosynthesis of Representative Natural Products/Drugs Involving Algae P450 and CD/DVD-ROM P450
Link of the Paper: https://www.sciencedirect.com/science/article/pii/S2211383522000260
The above two papers were supported by the Starting Fund of Binzhou Medical University (No.BY2021KYQD25 and BY2021KYQD28), the National Natural Science Foundation of China (No.31972815, 42176124) and the Major Basic Research Project of Shandong Natural Science Foundation (No.ZR2019ZD17, ZR2020ZD23).
SOURCE: School of Pharmacy (Wine School)
BY: Zhang Hao
