The latest research result of Prof. Yin Yancun’ s team from the Department of Human Anatomy, School of Basic Medical Sciences, titled DNAJC10 Maintains Survival and Self-renewal of Leukemia Stem Cells through PERK Branch of the Unfolded Protein Response, has been published in Haematologica, a top medical journal.
Considering Leukemia stem cells (LSCs) are closely related to occurrence, development, drug resistance and relapse of Leukemia, it is of great significance to elucidate the pluripotent regulation mechanism of LSCs for targeting LSCs and clinical therapy of Leukemia. The team finds through bioinformatic analysis that DNAJC10, a member of the HSP40 family, has an elevated expression level in LSCs and acute myeloid leukemia (AML) and that its high expression correlates with poor prognosis.
Associate Prof. Li Minjing and two postgraduate students of Grade of 2020, Wu Xingli and Chen Meiyang, are the co-first authors of the paper; and Prof. Yin Yancun and Prof. Kim Chang-soo are the corresponding authors. This study has been supported by the National Natural Science Foundation of China, the Key Project of Shandong Provincial Natural Science Foundation, and the Youth Creative Talent Cultivation Program of Shandong Province Higher Education Institutions.
SOURCE:The Department of Science and Technology